Reviews
Summary
Positives
- In the DELong#3 placebo-controlled pilot, long-haulers taking VSL#3 sachets twice a day for four weeks had significantly lower Chalder Fatigue Scale scores that persisted four weeks after stopping medRxiv DELong#3.
- An IBS trial found VSL#3 reduced colonic permeability and abdominal pain, mechanisms relevant to leaky-gut symptoms in Long COVID Frontiers in Pain Research.
Negatives
- A review of post-COVID probiotic data flagged that the VSL#3 fatigue pilot was small (n=38) and not powered to detect harms or non-fatigue outcomes MDPI Molecules review.
Hurdles & Side Effects
- The protocol requires two cold-chain sachets daily, which is expensive and logistically taxing for housebound patients medRxiv DELong#3.
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