Reviews
Summary
Positives
- A long-hauler reported that thiamine megadosing (up to 500mg 2x/day) resolved gastroparesis, POTS symptoms, polyneuropathy, and restless legs, describing B1 as a significant piece of their recovery Reddit.
- A patient with progressive neuro symptoms for 2 years reported that supplementing B1 at 300–400mg daily began reversing muscle stiffness, brain fog, and digestive issues Reddit.
Negatives
- A commenter noted they take a large-dose thiamine supplement daily and have seen no marked improvement in their POTS symptoms Reddit.
Hurdles & Side Effects
- There is a “thiamine paradox” — refeeding thiamine can temporarily worsen symptoms and disrupt electrolytes, requiring careful titration with magnesium and potassium support Reddit.
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