Positives

• In an open-label trial of refractory CIRS, patients on VIP nasal spray normalized C4a, TGF-beta-1, VEGF, and MMP-9 and reported quality-of-life gains in 100% of cases Surviving Mold.
  
  
• Patients who used intranasal VIP after completing earlier Shoemaker steps showed restored grey-matter volume on MRI follow-up Surviving Mold.
  
  

Negatives

• Patients commonly notice nasal irritation, mild headache, dizziness, palpitations, and a brief detox-like worsening early in dosing Surviving Mold.
  
  
• Because VIP is a potent vasodilator, patients with already-low blood pressure can feel lightheaded and have to titrate slowly Surviving Mold.
  
  

Hurdles & Side Effects

• Patients are told VIP is only safe and effective once all 11 prior Shoemaker steps (mold avoidance, binders, MARCoNS clearance, statin, etc.) are complete, which gates many people out for years Surviving Mold.
  
  
• VIP nasal spray is not FDA-approved and must be obtained from a compounding pharmacy by prescription, leaving patients paying out of pocket Surviving Mold.