Positives

• A Crohn's patient who had cycled through prior biologics described this anti-IL-12/23 antibody as her "easiest patient experience," reaching first-time remission and noting incidental brain-fog improvement Drugs.com.
  
  
• Many IBD users reported that response begins by week six and that 67% of reviewers rated their overall experience positively Drugs.com.
  
  

Negatives

• A patient four weeks into her loading dose reported that fatigue was "almost too much to bear" and made it hard to get out of bed despite Crohn's symptom improvement Drugs.com.
  
  
• Some users reported headaches, hair thinning, and pale skin that emerged weeks into therapy and persisted between injections Drugs.com.
  
  

Hurdles & Side Effects

• Patients with secondary Long COVID brain fog and IBD overlap reported that prescribers would only authorize the drug for the IBD indication, even when LC symptoms had been the more disabling problem Crohns Colitis Foundation.
  
  
• A user reported needing to shorten her injection interval from every 8 weeks to every 6 weeks for sustained remission, which insurance initially refused to cover Drugs.com.