Positives

• A long-hauler with a genetic mitochondrial mutation started ubiquinol 200mg and noticed improvement within a day, with others around him also noticing; his brother started it and wrote “I’m a new person” the next day Reddit.
  
  
• A nurse with Long COVID reported that ubiquinol was part of a supplement stack that helped manage energy and brain fog, making it possible to start returning to work after months of being bedbound Reddit.
  
  
• A patient taking 100mg ubiquinol daily reported it “greatly reduced my brain fog and widened my daily capacity before I trigger PEM” Reddit.
  
  

Negatives

• A patient who switched from ubiquinone (CoQ10) to ubiquinol at 300mg experienced “one of the worst crashes I’ve had,” with excruciating pain all over their body Reddit.
  
  
• A patient had the same experience switching forms, confirming that the ubiquinol form specifically triggered a severe crash despite ubiquinone working well Reddit.
  
  

Hurdles & Side Effects

• The original poster emphasized that standard CoQ10 (ubiquinone) had no effect on him, and that ubiquinol’s superior absorption was critical, suggesting patients who failed CoQ10 trials should try the ubiquinol form specifically Reddit.