Positives

• In three case reports of severe ME/CFS, patients receiving oral colostrum macrophage-activating factor described significant improvement in fatigue, muscle pain, and stomach pain without adverse effects Ar.
  
  
• Patients in a 2023 randomized trial of bovine colostrum plus hen egg white described major rapid reductions in joint pain, malaise, chest pain, and profound fatigue during early COVID PMC.
  
  

Negatives

• Some patients describe gut symptoms including bloating and loose stools when first starting colostrum-derived transfer factor products RTHM.
  
  
• Patient reviewers on WebMD reported no perceptible immune benefit despite months of consistent use, with some feeling worse WebMD.
  
  

Hurdles & Side Effects

• Patients with dairy allergies must avoid colostrum-derived transfer factor entirely RTHM.
  
  
• Quality varies widely between brands and patients describe difficulty verifying actual immunoglobulin content of products Ammes.