Positives

• One person managing CFS with post-exertional malaise reports that TMG “genuinely helps” reduce the intensity of crashes, noting that taking half a scoop daily and a full scoop after exertion minimizes symptoms Reddit.
  
  
• An individual with CFS highlights that TMG is believed to “increase oxygen saturation in muscles,” which may benefit those with low levels due to their condition Reddit.
  
  

Negatives

• Patients on TMG commonly describe gastrointestinal side effects including nausea, diarrhea, bloating, dyspepsia, vomiting, and stomach discomfort, especially at the higher doses studied for homocysteine reduction. Examine.com.
• Patients on TMG commonly see fasting homocysteine drop by roughly 12 percent, but those on aggressive 6 g/day dosing commonly see LDL cholesterol and triglycerides rise — so Long COVID patients with cardiovascular concerns face lipid changes. PMC.

Hurdles & Side Effects

• One patient noted that starting with a full scoop of TMG daily was “too much,” leading to an overestimation of their capabilities due to feeling better initially Reddit.