Positives

• ME/CFS and Long COVID patients use tizanidine as a “sleep aid” with documented central nervous system effects Phoenix Rising.
• Patients with severe ME/CFS, Long COVID, and dysautonomia report benefit for leg pain management Reddit.

Negatives

• Roughly half of patients on tizanidine commonly report sedation, with 1 in 10 rating it severe enough to discontinue FDA.
• Dry mouth is reported by 49% of users and frequently lasts long enough to push patients to discontinue Drugs.com.
• There is no published Long COVID trial evidence supporting tizanidine, and patients describe orthostatic hypotension and morning grogginess as common reasons to stop Drugs.com.

Hurdles & Side Effects

• Tizanidine worsens dysautonomia symptoms, particularly after adrenaline surges in sensitive POTS patients Reddit.
• Adoption remains rare in the POTS community, representing less than 1% of tracked medication usage Reddit.