Positives

• Patients with brain fog from neuroinflammatory conditions describe improvements in focus and energy within days to a few weeks of starting the Rg3/NR nasal spray.
  
  
• One patient reported noticeable clarity and alertness within 15-30 minutes of dosing, with cumulative gains over months.
  
  

Negatives

• Patients sometimes report nasal irritation or no perceptible effect, particularly when the underlying driver of brain fog is unaddressed.
  
  
• A patient reported that benefits faded after stopping, suggesting the spray manages symptoms rather than reversing the underlying inflammation.
  
  

Hurdles & Side Effects

• Synapsin is a compounded medication, not an FDA-approved drug, so quality varies by compounding pharmacy.
  
  
• Patients describe needing a prescribing clinician familiar with the formulation, and ongoing cost can be significant.