Positives

• A patient who developed heart palpitations and a jittery sensation about 2-3 hours after each immediate-release T3 dose tolerated SR-T3 without those cardiac symptoms Frontiers.
  
  
• A long-term user reported being on SR-T3 twice daily for nearly five years with FT3 just above the top of the range and a stable life on the regimen Paul Robinson.
  
  

Negatives

• A patient with Hashimoto's and a leaky gut found slow-release T3 hard to absorb consistently, leaving them functionally under-dosed despite labs that looked adequate Dr. Izabella Wentz.
  
  
• A patient on 20 mcg slow-release found only a few micrograms of T3 hit per hour, leaving them tired without realizing the dose was effectively too low Frontiers.
  
  

Hurdles & Side Effects

• A patient who had failed several IR-T3 trials had to find a compounding pharmacy that uses an HPMC matrix and may need refrigeration to preserve activity, which complicated travel and refills Makers Compounding.