Positives

• A forum member reported that sulfasalazine prescribed by his GP allowed him to walk upright again, easing joint and bone pain along with continual headaches that had not responded to NSAIDs Phoenix Rising.
  
  
• A second forum participant noted his anxiety, which he believed was driven by brain inflammation, dropped substantially on this NF-kB-inhibiting DMARD Phoenix Rising.
  
  

Negatives

• A patient developed peripheral neuropathy with numbness and tingling in her hands and feet, requiring discontinuation PMC.
  
  
• In a Canadian RA cohort 30% of patients did not see a major fatigue improvement, and some experienced fatigue as a side effect of the medication itself CreakyJoints.
  
  

Hurdles & Side Effects

• A forum member noted that the drug depletes folate and recommended supplementing throughout treatment to avoid worsening fatigue and macrocytic anemia Phoenix Rising.
  
  
• A patient described the slow titration up to the full daily dose, with bothersome GI symptoms in the first weeks before stabilization NHS.