Positives

• Animal models show that 4-PBA restored peroxisome function in macrophages and mitigated lung inflammation and fibrosis after viral infection, with patients in adjacent fields reporting reduced ER-stress symptoms, per a GEN news report.
  
  
• Patients using sodium phenylbutyrate as a chemical chaperone for protein-folding disorders describe reduced fatigue and improved exercise tolerance, per a PMC review on conformational disease.
  
  

Negatives

• Patients on Buphenyl frequently describe an extremely unpleasant taste, body odor, and amenorrhea, with appetite loss often limiting adherence, per Drugs.com Buphenyl monograph.
  
  
• Patients also describe nausea, vomiting, and abdominal pain that can be hard to distinguish from underlying GI symptoms, per Amgen's Buphenyl patient information.
  
  

Hurdles & Side Effects

• Branded Buphenyl can run over $13,000 per 266g jar and the generic still averages roughly $6,800 per 250 tablets, leaving patients dependent on assistance programs, per Drugs.com price guide.