Positives

• An ME/CFS patient on Xyrem for six months reported it effectively restored deep sleep, with 75% of comparable patients in a series experiencing significant fatigue relief PubMed.
  
  
• Fibromyalgia patients in a 14-week trial reported a greater than 30% drop in pain plus reduced fatigue and sleep disturbance PMC.
  
  

Negatives

• A user described worsening POTS symptoms and bladder twinges that forced breaks from dosing Phoenix Rising.
  
  
• Patients flagged the amnestic and abuse-potential profile as a reason their clinicians declined to prescribe it Phoenix Rising.
  
  

Hurdles & Side Effects

• Community advice stressed staying on each dose for 2 weeks before titrating up because the medication is potent and requires slow body adjustment Phoenix Rising.
  
  
• Patients described the REMS protocol as finicky, requiring careful midnight dosing, label defacement, and mandatory training videos Phoenix Rising.