Positives

• One patient reported losing roughly 44 pounds on Rybelsus despite needing to manage initial nausea and intermittent constipation as the dose climbed WebMD.
  
  
• A patient combining Rybelsus with other diabetes meds saw their A1C fall from 13.5 to 8.1 in under a month while finally feeling less hungry WebMD.
  
  

Negatives

• Patients described dry mouth and a persistent unpleasant taste that lingered into the night and made the morning tablet harder to swallow WebMD.
  
  
• One reviewer reported gastroparesis-like symptoms and monthly bouts of cramping and alternating constipation/diarrhea on the oral tablet WebMD.
  
  

Hurdles & Side Effects

• The protocol of taking Rybelsus on an empty stomach with no more than 4 oz of water and waiting 30 minutes before eating proved difficult to maintain consistently Mayo Clinic.
  
  
• A patient who already had post-COVID morning nausea found Rybelsus's required morning fasting window worsened it enough to consider asking their clinician about an evening switch Drugs.com.