Positives

• In the original RPAH study, 75% of patients with chronic hives and angioedema reported being symptom-free after six months on the low-chemical protocol Diet vs Disease.
  
  
• A 2025 dietetic audit reported patients experienced meaningful gut and extra-intestinal symptom improvement during the elimination phase Journal of Human Nutrition and Dietetics.
  
  

Negatives

• A patient blogger described failing both the amine and salicylate challenges within two days, leaving them disheartened about food options My Failsafe Life.
  
  
• The same dietetic audit documented 24% of patients losing 2-10 kg unintentionally and many staying restricted for 2-78 weeks PMC.
  
  

Hurdles & Side Effects

• Patients describe how exhausting it becomes to cook every meal from scratch and to find any drink besides water that does not trigger symptoms My Failsafe Life.
  
  
• Without an experienced dietitian, patients risk prolonged unnecessary restriction, limited food variety and nutritional inadequacy MEpedia.