Positives

• One patient with dysautonomia noticed a “clear reduction in quad and thigh pain” after using mestinon for a few months, which significantly improved their ability to engage in daily activities and exercise Reddit.
  
  
• A patient with muscle weakness due to Long COVID found that their symptoms “disappeared” while taking mestinon, with symptoms returning when the medication was paused Reddit.
  
  
• A patient with ME/CFS and orthostatic intolerance reported that after two months on mestinon, they were able to “leave the house” again after being housebound for nine months Health Rising.
  
  
• In another report, a patient with fibromyalgia and CFS in New Zealand experienced “more hours of useful time” and improved alertness and brain function while taking mestinon, as well as relief from constipation Health Rising.
  
  
• A long-term ME/CFS patient was able to resume running, gym workouts, and cross-country skiing without experiencing post-exertional malaise after starting mestinon, and also noted improved sleep and normalized heart rate Health Rising.
  
  

Negatives

• One patient tried mestinon for several days without any noticeable benefits, only experiencing "unpleasant side effects" and no improvement in their main symptoms Reddit.
  
  
• In another report, a patient noted that taking mestinon at a dose of 180mg for five months resulted only in diarrhea, without any other benefits Reddit.
  
  

Hurdles & Side Effects

• A patient experienced muscle spasms and eyelid twitching when increasing their mestinon dose too quickly Health Rising.
  
  
• One person reported muscle twitching, cramps, and IBS symptoms such as abdominal pain and diarrhea as side effects of mestinon Health Rising.