Positives

• One individual shared that after starting pycnogenol, they experienced a significant improvement, describing it as “like a night and day switch” from being constantly fatigued to being able to engage in daily activities like exercising and cleaning Reddit.
  
  
• Another long COVID patient noted that after taking pycnogenol, they felt their blood circulation might be improving, although they were still early in their treatment Reddit.
  
  
• A patient reported feeling “around 85% cured” after using pycnogenol, although they still sought additional energy and better sleep Reddit.
  
  

Negatives

• Long COVID patients on Pycnogenol in the 2025 PYCNOVID cohort saw a median health-status improvement of only 5.4 units versus 7.9 units in the placebo group, with no significant clinical benefit for post-COVID condition medRxiv.
• One reviewer reported their systolic blood pressure rose by 25 points after starting the supplement WebMD.

Hurdles & Side Effects

• One patient noted that they began feeling better almost immediately after starting pycnogenol, suggesting that early access to the supplement might be beneficial Reddit.