Positives

• A patient with ME/CFS experiencing premenstrual exacerbation found that bioidentical oral micronized progesterone significantly reduced the severity of their premenstrual PEM, describing the previous symptoms as “sheer brutality” Reddit.
  
  
• An individual with ME/CFS noted that progesterone contributed to “deeper sleep and increased calmness,” enhancing their overall well-being Reddit.
  
  
• A user with asthma and low progesterone levels reported that taking bioidentical progesterone sublingually since June helped them “sleep better,” though other improvements were minimal Reddit.
  
  

Negatives

• A patient reported that bioidentical progesterone “didn’t do much” for their symptoms, indicating variability in its effectiveness Reddit.
  
  

Hurdles & Side Effects

• One individual noted that fatigue returned after stopping progesterone, raising questions about whether continuous daily use would be beneficial Reddit.