Positives

• A long-hauler who assembled a supplement stack specifically targeting PEM and brain fog included phosphatidylserine (300mg) for cognitive support, reporting that their overall protocol “helped immensely with PEM” after sustained use Reddit.
  
  

Negatives

• One patient taking phosphatidylserine as part of a multi-supplement protocol noted they were considering suspending it due to concerns about potential side effects, indicating uncertainty about its net benefit Reddit.
  
  

Hurdles & Side Effects

• A patient taking phosphatidylserine as part of a multi-supplement protocol found its effects difficult to assess independently, since they were simultaneously adjusting several other cognitive support supplements and could not isolate what to attribute to phosphatidylserine specifically Reddit.