Positives

• A long-form Long COVID patient case account described intravenous ozone via major autohemotherapy as having “saved me at likely my worst with Long COVID,” with the patient reporting being “brought back to life” after the first IV and continuing for 25-30+ treatments Long C Foundation.
  
  

Negatives

• No FDA approval exists for ozone in the US, and most published evidence comes from European and Latin American clinics; large randomized placebo-controlled US trials have not yet been completed PMC.
  
  

Hurdles & Side Effects

• Major autohemotherapy requires withdrawing 100-200 mL of blood, mixing with medical-grade ozone, and reinfusing through the same IV access; absolute contraindications include pregnancy and severe G6PD deficiency due to hemolysis risk Frontiers in Medicine.
  
  
• A typical 10-session MAH course at an integrative-medicine clinic costs $2,000-$5,000 out of pocket; some patients pursuing the German/Mexican clinic protocols (10-30+ sessions plus apheresis adjunct) spend $10,000-$25,000 including travel Grassroots Functional Medicine.