Positives

• One practitioner posted positive results from their Long COVID IV-ozone patients, with several patients also reporting personally that they noticed improvements in fatigue and brain fog after a course of treatment Mayo Clinic Connect.

Negatives

• On Mayo Clinic Connect, one Long COVID patient reported trying vitamin infusions and ozone therapy for four months with no relief, and another with post-COVID small fiber neuropathy said ozone left their nerves with extreme excitability and their anxiety “through the roof” Mayo Clinic Connect.
• Long COVID patients are being sold ozone therapy through online support networks despite no adequate follow-up data, with some spending large sums and reporting their health worsened afterward The Conversation.

Hurdles & Side Effects

• Rectal insufflation is generally well tolerated, with the main reported issues being slight meteorism (gas) and feeling of bloating that subsides spontaneously within 1-2 hours; no serious adverse effects have been documented in published series PMC.
  
  
• Rectal insufflation is performed in a clinic setting (3-5 minute insufflation per session, 12-30 sessions per course) and typically costs $80-$150 per session; some practitioners teach home protocols using medical ozone generators (~$1,500-$3,000) for chronic patients who can’t commute The Wellness Lab.