Positives

• A long-hauler described “nearly overnight improvement” in Long COVID symptoms after starting Wegovy (semaglutide), with less swelling, reduced facial flushing, and more energy within days of the first dose Reddit.
  
  
• A patient commented that Wegovy “takes away my MCAS and lowers all my neuro inflammation symptoms,” describing it as the first treatment that worked after four years of illness Reddit.
  
  

Negatives

• A long-hauler reported that Ozempic caused uncontrollable vomiting severe enough to require an ER visit, describing it as one of the worst treatment reactions they experienced Reddit.
  
  
• One patient one month into semaglutide reported that it did not help with Long COVID symptoms and primarily caused further appetite suppression and nausea on top of their existing issues Reddit.
  
  

Hurdles & Side Effects

• A UK-based long-hauler described the difficulty of accessing GLP-1 medications for Long COVID, as private weight loss clinics require a minimum BMI and most doctors are unfamiliar with the off-label use for neuroinflammation Reddit.