Positives

• In a placebo-controlled trial, perimenopausal women taking 300 mg of oral micronized progesterone at bedtime fell asleep faster and slept more deeply, with allopregnanolone acting on GABA receptors Nature.
  
  
• A patient reported great sleep, no depression or anxiety, and no more hot flushes after a few months on Prometrium Drugs.com.
  
  

Negatives

• A patient described severe insomnia and an extreme depressive state with water retention and constipation while on Prometrium, the opposite of the intended effect Drugs.com.
  
  
• A reviewer experienced anxiety so intense she could not form words and had panic attacks after switching from oral to vaginal Prometrium WebMD.
  
  

Hurdles & Side Effects

• A patient seeking the sleep benefit found the prescription Prometrium only comes in 100 and 200 mg capsules, pushing her toward a compounded sustained-release version that her insurer would not cover PMC.