Positives

• One patient dealing with POTS-related nausea finds that ondansetron not only alleviates nausea but also helps calm anxiety attacks, describing the relief as “obviously helps” Reddit.
  
  
• Someone with ME/CFS reports that ondansetron surprisingly helped with their flu-like symptoms, including nausea and dizziness, noting it was “to my great surprise” Reddit.
  
  

Negatives

• A patient taking ondansetron daily for nausea reports experiencing “MAJOR constipation” and headaches as side effects, which affected their overall experience with the medication Reddit.
  
  

Hurdles & Side Effects

• Patients trying ondansetron for POTS commonly find no robust supporting literature for that off-label use, emphasizing the need for proper follow-up when using it for this diagnosis Reddit.