Positives

• A patient described nystatin escalating to 2 million units three times daily as helpful for suspected candida overgrowth, with the topical/non-absorbed nature making it gentler than systemic antifungals Buscher MD.
  
  
• A patient noted nystatin's low cost and minimal systemic absorption made high-dose oral protocols feasible for extended use PMC.
  
  

Negatives

• A patient reported Herxheimer-style die-off reactions were very common when ramping nystatin doses, including flu-like malaise and worsened brain fog Candida Diet.
  
  
• A patient described the bitter taste of high-dose oral suspension as nearly intolerable across four-times-daily dosing Drugs.com.
  
  

Hurdles & Side Effects

• A patient noted few clinicians outside functional medicine will prescribe the 1-2 million IU/day candida-hypersensitivity protocol NEJM.
  
  
• A patient described needing weeks-to-months of strict adherence plus dietary restriction to see effect Buscher MD.