Positives

• A patient reported NDT controlled hypothyroid symptoms better than levothyroxine, with improved energy on Acella's formulation Natural Thyroid Guide.
  
  

Negatives

• Patients on recalled sub-potent lots developed return of fatigue, cold intolerance, weight gain, and depression FDA.
  
  
• Acella received 43 reports of serious adverse events linked to potency variability Fierce Pharma.
  
  

Hurdles & Side Effects

• Both sub-potency (under 90%) and super-potency (up to 115%) recalls force patients to re-titrate doses with new bloodwork Medscape.
  
  
• Many endocrinologists refuse to prescribe NDT, leaving patients to seek out functional medicine clinicians FDA.