Positives

• One patient report describes that NADH provided significant relief from fatigue, although they were curious about how long it typically takes for others to notice improvement Reddit.
  
  

Negatives

• One ME/CFS patient took 25mg sublingual NADH regularly with no negative effects but also no positive effects, and another reported NADH worked briefly then stopped working Phoenix Rising.
• One patient reported NADH helped energy for about 10 days a decade ago, then stopped helping, and never produced a noticeable benefit on any subsequent retry over the years Phoenix Rising.
• One user tried 50mg sublingual NADH and developed a severe headache stronger than they had ever experienced, leading to immediate discontinuation Phoenix Rising.
• Patients with CFS on oral NADH commonly see reduced anxiety and lower max heart rate after a stress test but no change to other clinical variables or global functional performance, suggesting energy-system claims are overstated for ME/CFS and Long COVID overlap PubMed.
• Oral NADH is largely degraded by stomach acid, which is why IV NAD+ protocols at $150-500 per session are pushed instead, and patients trying oral NADH often see far smaller effects than expected.

Hurdles & Side Effects

• Some individuals have expressed concerns about the “cost or affordability” of NADH, which may limit access for some patients Reddit.