Reviews
Summary
Positives
- In a double-blind IBS trial the EcN responder rate exceeded placebo, with most patients reporting reduced bloating after about four weeks PMC IBS trial.
- A prospective cohort of 668 children rated tolerability as good-to-very-good in over 90% of cases, suggesting it is well accepted long-term Pediatric data collection.
Negatives
- Lab studies show Nissle 1917 carries the pks island and produces colibactin, a DNA-damaging genotoxin linked to colorectal cancer pathways, raising long-term safety questions mSphere Toxic Friend.
Hurdles & Side Effects
- Patients report initial bloating and gas during the slow capsule titration, and the strain is not stocked by US pharmacies so it must be imported PMC IBS trial.
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