Its an ongoing process

I think MTHFR affects comt/dopamine-adhd type symptoms, methylation and choline to act formation affecting circadian rhythm and under/over methylation is either impacted or is the root cause of energy, vagus nerve, memory issues. Most people have an MTHFR SNP but I think covid throws the process completely put of balance. This is why some people have low iron and others have high iron/ferritin post covid. Niacin is affected by MTHFR and that affects the krerb cycle (or it's the other way around. I'm having a slow head day) that affects iron/haemoglobin. MTHFR also affects the heart according to a cardiac nurse friend. I'm slow COMT and have 4 MTHFR SNPs. I am now very sensitive to methyl groups including melatonin and fish oil. Methlycobalmin used to be fine but now I can barely handle ¼ low does hydroxycob­almin. Creatine makes me both fidgety and bone weary even at 1mg (methyl donor). I'm slowly able to increase b vits and push them through the methylation cycle but it's slow and needs more breaks than periods of supplement­ation. Undermethy­lators might have an easier time at recovery with sAME and folate and Methlycobalmin.