Positives

• A patient noted that after experiencing unusual symptoms following vaccination, MSM provided relief similar to what others in their community experienced Reddit.
  
  

Negatives

• Patients on MSM commonly describe upset stomach and diarrhea as the most frequent adverse effect, often without meaningful joint-pain relief Drugs.com.
• Patients with knee osteoarthritis on MSM commonly see only modestly larger pain reduction than placebo, matching forum reports of no clear benefit PubMed.
• Patients have reported additional adverse effects including headaches, increased blood pressure, elevated liver enzymes, easy bruising on blood thinners and insomnia when taken at bedtime WebMD.
• Patients on MSM are commonly told by arthritis charities that the evidence is lacking and we don’t know for sure that taking MSM helps any of the conditions it is marketed for Versus Arthritis.

Hurdles & Side Effects

• Some users expressed difficulty in obtaining MSM, with questions frequently arising about where to find it and how to use it effectively Reddit.