Positives

• A patient with post-COVID neurological symptoms, including vertigo and brain fog, reported that montelukast significantly improved their condition, with the “brain fog nearly completely gone” after starting the medication Mayo Clinic Connect.
  
  
• One person dealing with long COVID symptoms, including dizziness and difficulty walking, found montelukast to be one of the “most impactful treatments” for resolving their vertigo and foggy feeling Mayo Clinic Connect.
  
  
• A patient with ME/CFS and MCAS noted that montelukast helped reduce wheezing and abdominal cramping by blocking leukotriene C4 Phoenix Rising.
  
  

Negatives

• A patient experienced “severe depression” after taking montelukast for six days, describing it as the worst mental state during their illness journey Reddit.
  
  
• One person reported that montelukast might have contributed to their insomnia, although they were uncertain due to multiple life changes at the time Phoenix Rising.
  
  

Hurdles & Side Effects

• Some patients reported experiencing vivid dreams and severe depression shortly after starting montelukast, which may pose a barrier to continued use Reddit.