Positives

• In a 200-patient ME/CFS series, 77.5% reported significant fatigue improvement after oxygen-ozone autohemotherapy, with 43.5% moving from worst to best FSS scores AMMES.
  
  
• PASC patients in a 100-patient registry reported improved fatigue without adverse effects after a course of ozonated blood injections AMMES.
  
  

Negatives

• A long COVID patient who completed 20 treatments in 30 days reported no improvement in fatigue or other symptoms despite the protocol AMMES.
  
  
• Patients noted that intramuscular MAH delivers a much smaller dose than major autohemotherapy, which some clinicians considered insufficient for severe cases The Lancet Regional Health.
  
  

Hurdles & Side Effects

• Patients reported that ozone therapy is not FDA-approved for these uses and is rarely covered by insurance, requiring out-of-pocket payment PMC.
  
  
• Finding a trained integrative clinic offering MAH was difficult outside major cities, especially in the U.S. PubMed.