Positives

• One person experiencing Long COVID symptoms noticed an improvement in “clarity of mind” and a significant reduction in tinnitus, along with increased energy and improved mood, after starting methylene blue Reddit.
  
  
• A patient reported “better mood and amazing sleep” as a result of using methylene blue, suggesting it positively impacted their overall well-being Reddit.
  
  
• One patient found that methylene blue was “working so may stick with it,” indicating a positive response to the treatment Reddit.
  
  
• One person noted that while working remotely, they experienced no fatigue from commuting, although they still needed a midday nap, attributing this improvement to methylene blue Reddit.
  
  

Negatives

• A patient emphasized the importance of checking for drug interactions, particularly highlighting the risk of “serotonin syndrome” if methylene blue is taken with SSRIs Reddit.
  
  

Hurdles & Side Effects

• One patient reported starting at one drop of a 1% solution and titrating up to roughly 10 drops twice daily, while others stayed at just two drops morning and night; patients consistently warn to drink it through a straw to avoid blue-stained teeth and to never combine with SSRIs because of serotonin syndrome risk Phoenix Rising.
• Pharmacists and clinicians warn that aquarium-grade methylene blue can contain up to 11% contaminants and is unsafe to ingest, so patients are pushed toward USP/pharma-grade compounded capsules or troches from compounding pharmacies, and the FDA explicitly flags methylene blue as a potent MAO-A inhibitor that can trigger serotonin toxicity when combined with SSRIs, SNRIs, tramadol, or dextromethorphan Drugs.com.