Positives

• A 2024 case report documents a 41-year-old Long COVID patient with severe anxiety, depression, insomnia, joint pain, cognitive difficulties, and headache who experienced 20% symptom improvement after her first MDMA-assisted session, marked improvement after the second, and complete remission after a third session following a relapse Wiley.
  
  

Negatives

• A patient who completed MDMA-assisted psychotherapy wrote a candid MAPS bulletin titled “I Tried MDMA-Assisted Therapy, and I Still Have PTSD,” reporting that despite the experience being meaningful, two sessions did not bring full remission of her trauma symptoms.

Hurdles & Side Effects

• Treatment requires 8-12 hour supervised sessions with two therapists and weeks of preparatory and integration work; underground or unsupervised use carries significant risks of cardiovascular events, hyperthermia, and serotonin syndrome (especially with concurrent SSRIs/SNRIs) PMC.