Positives

• A patient called once-nightly dosing a game changer and 94% of RESTORE participants preferred Lumryz over twice-nightly oxybate Drugs.com.
  
  
• Patients reported waking feeling naturally rested without missing a second dose WebMD.
  
  

Negatives

• A patient described severe morning brain fog at 7.5 g doses, severe enough they could not go outside for hours WebMD.
  
  
• Bed-wetting and restless leg spasms were reported, complicating fluid management Drugs.com.
  
  

Hurdles & Side Effects

• Full sodium load (vs Xywav) raises blood pressure concerns for patients with cardiovascular risk FDA.
  
  
• REMS-only access through specialty pharmacy and Schedule III scheduling slow refills Lumryz.