Positives

• Lisinopril enters the Long COVID conversation mainly when patients develop post-COVID hypertension, and some do describe it as useful once the dose is titrated to where their blood pressure is finally controlled. Reddit.

Negatives

• The tradeoff is tolerability: fatigue, cough, and that loopy "I cannot function on this" feeling show up often enough that some patients switch away quickly. Reddit.

Hurdles & Side Effects

• Generic lisinopril runs roughly $4-$15 for a 30-day supply, making it one of the cheaper ACE inhibitors patients try when exploring the ACE2 hypothesis Drugs.com.
• Patients on lisinopril commonly report a persistent dry cough that can appear weeks or months after starting; reports range from 2.5% to 35% of users depending on the survey Drugs.com.
• Patients on lisinopril can develop hyperkalemia (high potassium) and are commonly told not to use potassium supplements or salt substitutes without checking with their doctor first Mayo Clinic.