Positives

• One ME/CFS patient titrated L-glutamine up to 40 grams per day by adding 10 grams per day to avoid stomach upset, sipping the mixture throughout the day, and reported gut healing benefits; a 10-gram-per-day maintenance dose was more common among other forum members Phoenix Rising.
  
  

Negatives

• A user tried L-glutamine at just 150 mg per day and had to abandon it after two days because it made her “extremely and unbearably aggressive and irritable,” even at that sub-therapeutic dose Phoenix Rising.
  
  
• A third patient reported that just 1 gram of glutamine caused severe depression, which she attributed to increased neural inflammation, and that her insomnia returned after a dose of the supplement Phoenix Rising.
  
  

Hurdles & Side Effects

• Forum members caution that L-glutamine can convert to glutamate in people with certain metabolic profiles, and that those with elevated glutamate or a history of glutamate sensitivity should approach the supplement carefully even at low doses Phoenix Rising.