Positives

• A long-hauler incorporated L-Glutamine as part of an ATP-support stack with BCAAs and creatine in powdered form before and after workouts, reporting it “helped immensely with PEM” Reddit.
  
  
• A patient with Long COVID reported that L-Glutamine appeared to help with energy levels and decreasing inflammation after about a year and a half of illness Reddit.
  
  

Negatives

• One long-hauler found that L-Glutamine was the only thing controlling their acid reflux, but every time they tried to stop taking it, the reflux returned within about a week Reddit.
  
  
• A patient diagnosed with SIBO reported that despite taking L-Glutamine for gut issues, their broader Long COVID symptoms — interrupted sleep, low energy, and anxiety — continued to worsen and required increased beta blockers Reddit.
  
  

Hurdles & Side Effects

• One user taking 4g of L-Glutamine twice daily alongside sodium butyrate for gut healing noted that the supplement regimen required careful timing away from food to be effective Reddit.