Positives

• A patient described feeling lighter in spirit without feeling spaced out, with stress edge reduced but no drowsiness WebMD.
  
  
• A self-described overthinker reported sceletium helped them get back to earth and think more reasonably WebMD.
  
  

Negatives

• Some users experienced no perceptible benefit, while others reported negative mood shifts and headaches WebMD.
  
  
• Patients on SSRIs face a serious serotonin syndrome risk because mesembrine acts as a serotonin reuptake inhibitor PMC.
  
  

Hurdles & Side Effects

• Users described a priming effect where the first few doses felt disappointing before benefits surfaced after several days PMC.
  
  
• Patients on antidepressants must clear sceletium with a clinician given documented contraindications with SSRIs and MAOIs OPSS.