Positives

• A calciphylaxis patient reported pain resolving within two weeks and lesions healing fully in twelve weeks on IV sodium thiosulfate PMC.
  
  
• Long COVID patients trying it off-label have described improved skin perfusion and less burning extremity pain after several infusions, attributed to its antioxidant and endothelial effects JAMA Network Open.
  
  

Negatives

• Patients commonly experience nausea during the infusion and some develop an anion-gap metabolic acidosis with repeated dosing PMC.
  
  
• A few users described post-infusion fatigue, garlic-like body odor, and low blood pressure that limited how often they could go in Taylor & Francis.
  
  

Hurdles & Side Effects

• Off-label use for endothelial repair is not covered by insurance, and patients pay out of pocket per infusion at integrative clinics Medscape.
  
  
• Standardized protocols don't exist outside calciphylaxis, leaving patients and providers guessing on dose, frequency, and duration JAMA Network Open.