Positives

• A patient on Mayo Clinic Connect described improvement in energy and brain fog after IV ozone therapy, attributing the benefit to enhanced mitochondrial activity and reduced oxidative stress Mayo Clinic Connect.
  
  

Negatives

• A patient reported adverse effects including extreme nerve excitability and severe anxiety after IV ozone treatment, illustrating that ozone’s controlled-oxidative-stress mechanism can backfire in highly sensitive patients Mayo Clinic Connect.
  
  
• Most of the published evidence is anecdotal or small-cohort, and ozone is genuinely toxic at higher concentrations — absolute contraindications include pregnancy and severe G6PD deficiency due to risk of hemolysis PMC.
  
  

Hurdles & Side Effects

• Major-autohemotherapy ozone treatment is performed in private clinics in the US (not FDA-approved); a typical 6-12 session course costs $1,500-$5,000 out of pocket, requires venous access for blood withdrawal and reinfusion, and is not covered by insurance The Wellness Lab.