Positives

• A safety survey of 70 patients found 78% rated their experience positive and 62% reported tangible health benefits attributed to the nasal spray PMC.
  
  
• A clinician with ME/CFS estimated that 80 to 90 percent of her patients gained roughly a 20% improvement in fatigue and cognition over 6 to 8 weeks of compounded intranasal glutathione Health Rising.
  
  

Negatives

• A Parkinson's patient who used the spray for several months reported no noticeable benefit and complained that it reeked of rotten eggs Michael J. Fox Foundation.
  
  
• In a Phase IIb trial, glutathione was not superior to placebo on Parkinson's rating scales, leaving efficacy in question PubMed.
  
  

Hurdles & Side Effects

• Patients commonly reported nasal irritation (about 18%), headaches (9%), and occasional nosebleeds, which can lead to discontinuation PMC.
  
  
• A patient must commit to compounded refills costing real money out of pocket, with one patient saying the expense pushed her to quit before knowing if it worked Michael J. Fox Foundation.