Positives

• One ME/CFS patient on Phoenix Rising reported that idebenone helped "immensely" with her energy levels and muscle function during the period she was taking it, framing it as a CoQ10 alternative Phoenix Rising.

Negatives

• That same patient later reported idebenone "stopped working" for her — a tachyphylaxis pattern she and other forum members have described with other mitochondrial-support supplements Phoenix Rising.

Hurdles & Side Effects

• Forum discussion notes that idebenone transfers electrons from complex II (succinate dehydrogenase) but not from complex I (NADH dehydrogenase) to complex III, which makes it functionally different from CoQ10 in patients whose mitochondrial dysfunction is concentrated at one complex versus another Phoenix Rising.