Positives

• A four-case series of ME/CFS patients reported attenuation of headache, general pain, and progressive improvement in brain fog beginning around 3 weeks of hydrogen gas inhalation and continuing through 9 weeks PMC.
  
  
• Long COVID patients using hydrogen-rich water reported reduced fatigue, although dyspnea did not significantly change in a controlled trial MDPI.
  
  

Negatives

• A controlled trial in Long COVID patients found hydrogen-rich water did not significantly improve dyspnea, suggesting respiratory symptom benefit may be limited or modality-dependent MDPI.
  
  
• Patients commonly report that effects are subtle and may not be perceptible without weeks of consistent twice-daily inhalation Wiley.
  
  

Hurdles & Side Effects

• Home molecular hydrogen inhalation units typically run $1,500-$5,000 with ongoing electrolyte refill costs, and there is no insurance coverage for Long COVID indications Wiley.
  
  
• Patients commit to 30-60 minutes of daily inhalation through a nasal cannula for several weeks before drawing conclusions, a meaningful time burden during PEM PMC.