Positives

• One ME/CFS patient reported that after a high-dose IV vitamin C infusion she could walk much farther and had a more active day than normal, with a “solid sense of strength” in muscles that were usually tired and exhausted Phoenix Rising.
  
  
• A patient reported going from “stiff, fatigued and heavy in the morning” to feeling energized and balanced after a high-dose vitamin C session, and said she experienced no post-exertional malaise from the activity increase the same day Phoenix Rising.
  
  

Negatives

• A third patient running a protocol of 50 gram IV vitamin C infusions twice weekly reported developing insomnia by the end of the first month of treatment, and eventually reduced her dosing schedule to manage the sleep disruption Phoenix Rising.
  
  
• A user on high-dose vitamin C developed oxalate problems over time and had to reduce her overall vitamin C intake, a well-known long-term risk of repeated high-dose protocols Phoenix Rising.
  
  

Hurdles & Side Effects

• High-dose vitamin C IV is distinct from the lower-dose vitamin C in Myers’ cocktail infusions; typical protocols run 25 to 100 grams per infusion and are delivered at integrative clinics rather than hospitals, usually without insurance coverage Phoenix Rising.
  
  
• Forum members note that patients with G6PD deficiency are at elevated risk of hemolysis from high-dose vitamin C IV and should be screened before the first infusion, and that oxalate accumulation is a known long-term risk requiring intermittent breaks or lower maintenance doses Phoenix Rising.