Positives

• A patient who started hookworm therapy in 2014 and titrated to roughly 150 worms reported, around month five, that chronic fatigue and brain fog resolved, body temperature stabilized, and her leukopenia cleared Wikipedia.
  
  
• In a multiple sclerosis trial, 12 of 16 subjects on Trichuris suis ova improved during treatment with a trend toward 35% fewer active MRI lesions and no serious adverse events PMC.
  
  

Negatives

• Three TSO subjects in a clinical trial developed mild grade-1 diarrhea or abdominal cramps that resolved on their own, and Necator hookworm patients reported temporary GI upset and risk of anemia at higher doses PMC.
  
  
• A patient hoping for durable benefit from TSO learned the worms only live a few weeks, so improvements faded unless dosing was repeated at intervals ScienceDirect.
  
  

Hurdles & Side Effects

• A self-treating patient had to source helminths internationally and self-titrate doses, since neither TSO nor Necator is FDA-approved and there are an estimated 6,000-7,000 worldwide self-treaters trading guidance through online communities Wikipedia.