Positives

• A patient using greater celandine alongside other Lyme herbs reported improved digestion and reduced upper-right abdominal discomfort attributed to liver-biliary support NIH LiverTox.
  
  

Negatives

• Multiple Lyme patients developed acute hepatitis with jaundice and elevated transaminases after one to six months of greater celandine use, with rapid recovery only after discontinuation PMC.
  
  
• A patient who restarted greater celandine after recovering from drug-induced liver injury experienced a recurrence of hepatitis on rechallenge PubMed.
  
  

Hurdles & Side Effects

• Patients on Lyme botanical stacks struggle to monitor liver enzymes frequently enough to catch the idiosyncratic injury greater celandine can trigger PMC.