Positives

• Traditional users describe graviola as helpful for joint pain, fever, and skin inflammation, with rodent studies confirming COX inhibition and nitric oxide reduction PMC.
  
  
• One Memorial Sloan Kettering integrative monograph notes patients use graviola for inflammation, infections, and pain, with evidence of analgesic and anti-inflammatory activity in animal models Memorial Sloan Kettering.
  
  

Negatives

• Reviewers note that despite cell and animal evidence, scientists do not yet know whether graviola works for cancer, infection, or inflammation in humans WebMD.
  
  
• Long-term graviola consumption has been associated with atypical Parkinsonism in epidemiologic studies from the Caribbean, an outcome patients should weigh seriously Memorial Sloan Kettering.
  
  

Hurdles & Side Effects

• Annonaceous acetogenins in graviola are neurotoxic and the herb should not be combined with antiparkinsonian or dopaminergic medications Memorial Sloan Kettering.
  
  
• Patients on antihypertensives or hypoglycemic agents face additive effects given graviola's blood-pressure and blood-sugar lowering Healthline.