Positives

• One patient reported that an original grape seed extract product had “the largest and most obvious immediate impact” of anything she had ever tried for her ME/CFS symptoms, though she noted that other brands of grape seed extract did not reproduce the effect Phoenix Rising.
  
  

Negatives

• Forum discussions note that grape seed extract is a potent source of proanthocyanidins and can help with pollen allergies when combined with quercetin, but that its effect profile varies widely between users Phoenix Rising.
  
  
• A user reported that grape seed extract caused terrible insomnia despite being taken early in the day, and another noted that it is high in salicylates and can be estrogenic, which caused problems for salicylate-sensitive patients Phoenix Rising.
  
  

Hurdles & Side Effects

• Grape seed extract and pycnogenol are often discussed together in the same forum threads because both are proanthocyanidin-rich, but patients note that brands vary considerably in both potency and carrier ingredients, and that salicylate-sensitive patients may react to grape seed extract even at low doses Phoenix Rising.