Positives

• Chronic rhinosinusitis patients reported significant drops in congestion, post-nasal drip, purulent discharge, halitosis, and chronic cough after starting gentamicin nasal irrigation ScienceDirect.
  
  
• Patients in the same series had fewer sinusitis flares, fewer hospitalizations, and needed fewer rescue oral antibiotics during follow-up ScienceDirect.
  
  

Negatives

• Patients new to nasal rinses described mild burning, stinging, redness, and itching at the application site during the first few uses UW Health Online.
  
  
• Measurable systemic gentamicin absorption was detected in irrigation users, raising ototoxicity and nephrotoxicity concerns for long-term users PubMed.
  
  

Hurdles & Side Effects

• Patients had to learn proper head positioning and rinse technique before they could tolerate the spray comfortably UW Health Online.
  
  
• Because it is not a stock product, patients had to source gentamicin nasal preparations through compounding pharmacies on prescription ScienceDirect.